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M9470073.TXT
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1994-07-02
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Document 0073
DOCN M9470073
TI Hyperperfusion and early technetium-99m-HMPAO SPECT appearance of
central nervous system toxoplasmosis.
DT 9409
AU Catafau AM; Sola M; Lomena FJ; Guelar A; Miro JM; Setoain J; Department
of Nuclear Medicine, Hospital Clinic i Provincial,; University of
Barcelona, Spain.
SO J Nucl Med. 1994 Jun;35(6):1041-3. Unique Identifier : AIDSLINE
MED/94253901
AB Three correlative 99mTc-HMPAO brain SPECT studies were performed on an
AIDS patient from the early stage of a CNS toxoplasma lesion to its
resolution after specific therapy. A hyperactive area in the right
parieto-occipital lobe appeared in the first SPECT study, matching the
heterogeneous T2-weighted image with Gd-DTPA enhancement reported on
MRI. Both studies were performed 3 days after the onset of neurological
symptoms when no abnormalities were found on a CT scan. This fact can be
explained by the hyperemia that occurs in the acute stage of
inflammation. Three months later, along with clinical improvement under
specific treatment, both MRI and brain SPECT were normal. No
hypoperfusion was seen in SPECT images, probably because the necrotic
phase of the toxoplasma lesion was not reached in this case.
DE Adult AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY/
*RADIONUCLIDE IMAGING Brain/RADIONUCLIDE IMAGING Case Report
Cerebrovascular Circulation Female Human Organotechnetium
Compounds/*DIAGNOSTIC USE Oximes/*DIAGNOSTIC USE Support, Non-U.S.
Gov't *Tomography, Emission-Computed, Single-Photon Toxoplasmosis,
Cerebral/PHYSIOPATHOLOGY/*RADIONUCLIDE IMAGING JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).